Permanent researcher, CRCN – CNRS
gaelle(dot)recher(at)institutoptique(dot)fr
Research interests / keywords
Cell self-organisation
Tissue biophysics
Physiomimetic morphogenesis
Microscopies (non linear, light sheet)
Microfabrication
Scientific responsabilities
Member of the board of the CNRS GdR ImaBio
Coordination of the workgroup ‘Imaging Multicellular Systems’
Education
PhD in Biology – 2010
University of Rennes 1
Master 2 in Neurosciences (Eq. to MSc) – 2006
Pierre & Marie Curie University, Paris
Previous labs
Postdoctoral scientist – 2015 November-2017 September
BioImaging and OptoFluidics Group, LP2N – UMR 5298
IOGS, CNRS & University of Bordeaux, Talence, FR
Advisor: Pierre Nassoy
Biophysics of cell assembly in confined & controlled environment
Postdoctoral scientist – 2014 May-2015 October
Magdalena Zernicka-Goetz Group
Department of Physiology, Development and Neuroscience & Gurdon Institute, University of Cambridge, UK
Advisor: Magdalena Zernicka-Goetz
Role of intracellular signalling during mouse & human embryo pre- to post-implantation development and establishment of two-photon imaging and 4D analyses of morphogenesis. Isaak Newton Trust Fellowship
Postdoctoral scientist – 2011 January-2014 June
Multiscale Dynamics in Animal Morphogenesis, BioEmergences
FRC2118 CNRS, Alfred Fessard Neurobiology Institute, Gif-sur-Yvette, FR
Advisor: Nadine Peyriéras
Neural progenitors in the zebrafish midbrain investigated with 3D+time two-photon microscopy & Two-photon and light sheet microscopy developments, artificial assistant conception
Research associate – 2010 January-December
Molecular chemistry to molecular photonics laboratory, UMR 6510, University of Rennes, FR
Advisor: Mireille Blanchard-Desce
FEDER European grants. Biological valorization of multichromophoric Bodipies with in vivo multiphoton imaging of xenopus tadpoles
PhD in Biology – 2006 October-2010 July
SCANING group
UMR 6026, CNRS, University of Rennes, FR
Supervisor: François Tiaho; co-supervisor: Pascal Benquet
Two-photon microscopy contribution to striated muscular tissue and nervous system studies
Master 2 (MSc) internship – 2006 January-June
Oheim-Ropert group
U603, Neurophysiology and New Microscopies Laboratory, INSERM, Paris, FR
Supervisor: Nicole Ropert
5-HT diffusion at central synapse: amperometric signal simulation
Publications
Articles
Andrique, L*, Recher, *, Alessandri, K, Pujol, N, Feyeux, M, Bon, P, Cognet, L, Nassoy, P, and Bikfalvi, A (2019). A model of guided cell self-organization for rapid and spontaneous formation of functional vessels. Science Advances, eaau6562.
Reichhardt, M P, Lundin, K, Lokki, A I, Recher, G, Vuoristo, S, Katayama, S, Tapanainen, J, Kere, J, Meri, S, and Tuuri, T (2019). Complement in human pre-implantation embryos: attack and defense. bioRxiv, 595561.
Shahbazi M, Scialdone A, Skorupska N, Weberling A, Recher G, Zhu M, Jedrusik A, Devito L, Noli L, Macaulay I, Buecker C, Khalaf Y, Ilic D, Voet T, Marioni J, Zernicka-Goetz M (2017) Pluripotent state transitions coordinate morphogenesis in mouse and human embryos. Nature
Hinaux H, Recher G, Alié A, Legendre L, Blin M & Rétaux S (2017) Lens apoptosis in the Astyanax blind cavefish is not triggered by defects in morphogenesis or community effect. PlosOne
Alessandri K*, Andrique L*, Feyeux M*, Bikfalvi A, Nassoy P & Recher G† (2017) All-in-one 3D printed microscopy chamber for multidimensional imaging, the UniverSlide. Scientific Reports
Joly J-S, Recher G, Brombin A, Ngo K & Hartenstein V (2016) Conveyor-belt neurogenesis: a conserved mode of generating a complex, homotopically patterned visual system in insects and vertebrates. Current Biology
Shahbazi M*, Jedrusik A*, Vuoristo S*, Recher G, Hupalowska A, Campbell A, Fishel S & Zernicka-Goetz M (2016) In vitro culture of human embryos reveals self-organization of the epiblast during implantation stages. Nature Cell Biology
Faure E*, Savy T*, Rizzi B*, Melani C*, Stasova O*, Fabrèges D*, Spir R, Hammons M, Cunderlik R, Recher G, Lombardot B, Duloquin L, Colin I, Kollar J, Desnoulez S, Affaticati P, Maury B, Boyreau A, Nief J-Y, Calvat P, Vernier P, Frain M, Lutfalla G, Kergosien Y, Suret P, Remesikova M, Doursat R, Sarti A, Mikula K, Peyriéras N & Bourgine P (2016) An algorithmic workflow for the automated processing of 3D+time microscopy images of developing organisms and the reconstruction of their cell lineage. Nature Communications
Recher G, Coumailleau P, Rouède D & Tiaho F (2015) Structural origin of the drastic modification of second harmonic generation intensity pattern occurring in tail muscles of climax stages xenopus tadpoles. Journal of Structural Biology
Recher G*, Jouralet J*, Brombin A, Heuzé A, Mugniery E, Hermel J-M, Desnoulez S, Savy T, Herbomel P, Bourrat F, Peyriéras N, Jamen F & Joly J-S (2013) Zebrafish midbrain slow-amplifying progenitors exhibit high levels of transcripts for nucleotide and ribosome biogenesis. Development
Rouède D, Bellanger J-J, Recher G & Tiaho F (2013) Study of the effect of myofibrillar misalignment on the sarcomeric SHG intensity pattern. Optics Express
Rouède D, Bellanger J-J, Schaub E, Recher G & Tiaho F (2013) Theoretical and Experimental SHG Angular Intensity Patterns from Healthy and Proteolysed Muscles. Biophysical Journal
Parthasarathy V, Fery-Forgues S, Campioli E, Recher G, Terenziani F & Blanchard-Desce M (2011) Dipolar versus octupolar triphenylamine-based fluorescent organic nanoparticles as brilliant one- and two-photon emitters for (bio)imaging. Small
Rouède D, Recher G, Bellanger J-J, Lavaut M-T, Schaub E & Tiaho F (2011) Modeling of supramolecular centrosymmetry effect on sarcomeric SHG intensity pattern of skeletal muscles. Biophysical Journal
Recher G, Rouède D, Schaub E & Tiaho F (2011) Skeletal muscle sarcomeric SHG patterns photo-conversion by femtosecond infrared laser. Biomedical Optics Express
Recher G, Rouède D, Tascon C, D’Amico LA & Tiaho F (2011) Double-band sarcomeric SHG pattern induced by adult skeletal muscles alteration during myofibrils preparation. Journal of Microscopy
Recher G, Rouède D, Richard P, Simon A, Bellanger J-J & Tiaho F (2009) Three distinct sarcomeric patterns of skeletal muscle revealed by SHG and TPEF Microscopy. Optics Express
L’hostis-Guidet A, Recher G, Guillet B, Al-Mohammad A, Coumailleau P, Tiaho F, Boujard D & Madigou T (2009) Generation of stable Xenopus laevis transgenic lines expressing a transgene controlled by weak promoters. Transgenic Research
Mongin O, Rouxel C, Robin AC, Pla-Quintana A, Krishna TR, Recher G, Tiaho F, Caminade AM, Majoral JP & Blanchard-Desce M (2008) Brilliant organic nanodots: novel nano-objects for bionanophotonics – art. no. 704006. 7040:4006-4006. SPIE Proceedings. Nanobiosystems: Processing, Characterization, and Applications
Tiaho F, Recher G & Rouède D (2007) Estimation of helical angles of myosin and collagen by second harmonic generation imaging microscopy. Optics Express
Patents
Andrique L, Recher G, Bikfavli A, Alessandri K, Feyeux M, Nassoy P (2017) Microfibre cellulaire creuse et procédé de fabrication d’une telle microfibre cellulaire creuse. FR 17 5194
Recher G, Alessandri K, Andrique L, Feyeux M, Nassoy P, Bikfavli A (2016) Chambre de culture et d’imagerie d’échantillons biologique. FR 16 63241
Feyeux M, Alessandri K, Recher G, Cognet L, Bezard E, Nassoy P (2016) Microcompartiment cellulaire et procédés de préparation. FR 16 61377